1216 Effect of intraoperative mitomycin C in recurrent pterigium: Long term follow-up

Purpose: To investigate two newly dcvcloppcd surgical tcchniqucs Ibr tbc rccotrstrtrctiotr cl' the limbal arrn liillowirtg removal o1'n ptcrygiutn itt terms of recurrertce rate. and comeal topographical changes. Mcllwcls: WC irrorlxctivcly comtxrrcd 57 conscctrtivc cirscs ot I:rmcllirr autohcn~toplasty (LAKI') to 40 consccutivc crtscs of lirrtbnl autotransplantation (LAT) associated to the transposition of superior bulbar conjunctiva following excision of a plerygium. Clinicnl outcome variables including best corrected visual acuity. refraction rind recut-rchcc ol pterygium were analyzed. In addition, changes in the comeal topography were monitored using the TMSl system (Tomey, France). Results: True rccurrertce o(pterygrum was observed in one case ol' the LAKP. but not in the LAT group In addition. 5 cnscs of tbc LAKE' group lhxl mnrkcd induced nstigtnntism t:8 to 13 dioptcrs). associ:tlcd to n tprbgrcssivc cc&n or 1111: dorxrr sitr. 111 1111: LAI' group. lwstopcrativc astigmatism was not signilicantly diTlerent liom preoperative values. Conclusion: LAT may be as effective as LAKP to prevent recurrences of pterygium and may avoid the risk fir significant induced astigmatism. Purpose: The aim of this study wa:s to evaluate the Long-term results of intraoperative administration of mitomycin C in the surgical treatment of patients with ona recurrence of pteryg~ium. Methods: 45 white patients with one recurrence of otervoium were included in the study. The " bare sclera technique " was pert&red and a sterile sponge soaked in a 4% mitomycin C solution was placed intraoperatively in the episcleral space for three minutes. A sex and age matched control group was used; the control group underwent only surgical excision. Recurrences were analyzed by thex' test and tf#e method of Kaplan Meyer (life-table analysis); the difference between survival curves was tested by the log-rank test. The x' test with Yates' correction or Fishers' exact test were used to analvze the difference in comolicatic'ns and side effects between the two groups. Results: 6 recurrences (12.5%) werg? observed in the mitomycin C treated patients and 16 (35.6%) in the control patients (P=O.O27)-after a mean postooerative follow-up of 30.55 i 13.70 months. The 24-and 46-month life-table success rates were 69% and E'3% in the mitomycin C treated group and 86% and 63% in the control group, respectively (P=O.O22). No severe side effects was checked during follow-up. 7 mitomycin C treated eyes (15.5%) manifested a superficial punctate keratitis in the early post-operative period (P=O.O16). Conclusiorxlntraoperative administration of mitomvcin C was useful in impmving the success rate after recurrent …